Bempedoic acid trials

4 studies from 2019 to 2023, with 17,324 people taking part. Results: 1 fewer heart events or deaths, 3 lipid or plaque goal met. Every summary comes from the trial's PubMed abstract.

All 4 studies

• CLEAR Outcomes2023 · Bempedoic acid · 13,970 people

  In statin-intolerant patients, bempedoic acid significantly lowered LDL cholesterol and reduced major adverse cardiovascular events compared with placebo, though it did not significantly reduce stroke or death, and was associated with more gout, gallstones, and modest increases in creatinine, uric acid, and liver enzymes.

  BenefitBempedoic acidUS-approved

• CLEAR Harmony2019 · Bempedoic acid · 2,230 people

  In statin-treated patients with ASCVD or familial hypercholesterolemia, adding bempedoic acid significantly lowered LDL cholesterol compared with placebo over 52 weeks without increasing overall adverse events, though it was linked to more treatment discontinuations and gout.

  Primary safety endpoint met; LDL-C loweredBempedoic acidUS-approved

• CLEAR Serenity2019 · Bempedoic acid · 345 people

  In statin-intolerant patients with high cholesterol, bempedoic acid 180 mg daily significantly lowered LDL cholesterol and other atherogenic lipids and inflammation markers compared with placebo, with a safety and muscle-symptom profile similar to or better than placebo.

  Primary lipid endpoint metBempedoic acidUS-approved

• CLEAR Wisdom2019 · Bempedoic acid · 779 people

  Adding bempedoic acid to maximally tolerated statin therapy significantly lowered LDL-C and other atherogenic lipid markers compared with placebo over 12 weeks, though cardiovascular outcome benefit was not assessed in this trial.

  Primary lipid endpoint metBempedoic acidUS-approved

Other medicines

• Statins
• Ezetimibe and bile acid binders
• PCSK9 inhibitors
• Lp(a) medicines
• CETP inhibitors
• Fibrates, omega-3 and niacin
• APOC3, ANGPTL3 and lomitapide
• Genetics and gene editing
• Meta-analyses

Search and filter all 106 studies in the trial database. Education only, not medical advice.